So i'I've played tons of Game Dev Tycoon, and I LOVE it. A good subject that would fit the Formula would be Films. You start off as an indie film maker and make films like you make games in Game Dev Tycoon. Eventually you can go to a bigger studio and hire your own positions, like Script Person (I don't know what the real position is called), Cameraman, Editor, and Producer.
A new feature Greenheart Games could add to the Tycoon formula is actors. You get to choose which actors you want in your films. Prominent actors could be used from the era (Like say for 80's you could use Judd Nelson). The Actors will cost money and the more you use them the less they cost. There could also be "loyalty" bonuses as well. If copyrights actually exist for actor's names than you could just parody them like Nudd Jelson or something like that.
Another feature could be The Oscars. It would be sort of like G3 in Game Dev Tycoon but much more prominent. If you actually won or got nominated for an Oscar it would help your earnings as a director.
Some new Genres could be Action, Romance, Comedy, Dramatic, Epic, Musical or anything else that i'm missing (maybe Story-Driven). Some Topics could be Fantasy, War, Music, Crime, or anything else you guys think of.
You would also have like a budget so you couldn't just make Lord of the Rings scale movies right off the bat.
Some of The Sliders could be like Story, Music, and Special Effects.
So yeah that's my idea let me know any opinions/changes in the comments and I hope you guys like the idea