One thing that has continually popped into my head every time I got to a new generation of consoles was that it’d be cool if I could start in that era. Currently the game starts somewhere in an era equivalent to the 1980s, simulating the life of companies like Electronic Arts and Ubisoft (if you don’t go bankrupt).
What I’d like to see is the ability to start in different decades, so that one can become a company like id Software in the 90s or an indie game developer in the 00s or 10s. This would allow the basic gameplay (making small games, limited genres, etc.) to take place in a completely new landscape and thus make the game feel like new again.